Panadol Night Film-coated Tablets, paracetamol 500mg, diphenhydramine hydrochloride 25mg. Indications: Short-term treatment of bedtime symptoms of cold and flu pain, rheumatic and muscle pain, backache, toothache, headache, menstrual pain. Dosage: Adults and children 16 years and over: 2 tablets, 20 minutes before bed. Children aged 12-15 years: 1 tablet, 20 minutes before bed. Minimum dosing interval between this and any other paracetamol containing product: 4 hours. Other products containing paracetamol may be taken during the day but the total daily dose of paracetamol must not exceed 4000mg for adults and 2000mg for children aged 12-15 years. Do not give to children under 12 years except on medical advice. Avoid use in elderly patients with confusion. Avoid use with other antihistamine-containing products. Do not use for more than 7 days without medical advice. Contraindications: Hypersensitivity to paracetamol or any of the other ingredients. Closed angle glaucoma, porphyria. Precautions: Hepatic or renal dysfunction/failure. Patients with depleted glutathione levels (e.g. eating disorders) or chronic alcoholism or sepsis. Avoid use with alcohol. Avoid concurrent use with sedatives (including hypnotics and anxiolytics), antimuscarinics and other antihistamines. Caution in those with epilepsy or seizure disorders, myasthenia gravis, narrow angle glaucoma, prostatic hypertrophy, urinary retention, asthma, bronchitis, COPD or with any form of glucose-galactose malabsorption or lactase deficiency. Avoid use of MAOIs within 2 weeks. Should not be used during pregnancy or lactation without medical advice.  Side effects: See SPC for full details.  All very rare: thrombocytopaenia, hypersensitivity reactions including anaphylaxis and skin rashes, angioedema, Stevens-Johnson syndrome and Toxic Epidermal Necrolysis, bronchospasm, hepatic dysfunction. Common: fatigue, sedation, attention disturbance, dizziness, unsteadiness, dry mouth. Frequency unknown: confusion, paradoxical excitation, GI disturbances, convulsions, headache, paraesthesia, dyskinesias, blurred vision, tachycardia, palpitations, muscle twitching, urinary difficulty, urinary retention, thickening of bronchial secretions. Overdose: Immediate medical advice should be sought in the event of an overdose, even if symptoms of overdose are not present. Legal Category: Pharmacy only. MA Number: PA 678/39/8. MA Holder: GlaxoSmithKline Consumer Healthcare (Ireland) Limited, 12 Riverwalk, Citywest Business Campus, Dublin 24. Text prepared: June 2021. Further information available on request. Trade marks are owned by or licenced to the GSK group of companies. Contains Paracetamol. Always read the label/leaflet.
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